U.S. 301/601 North

U.S. 601 (Broxton Bridge Road) combines with U.S. 301 (Main Highway) just ahead of the Bamberg city line.
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Main Highway leads U.S. 301/601 north 0.88 miles to U.S. 78 (Heritage Highway) in the Bamberg business district.
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U.S. 78 joins Bamberg with Denmark and Branchville as part of a cross state route between North Augusta and Charleston.
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Main Highway north at Dixie Avenue in Bamberg.
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McGee Street (Road 111) ties into U.S. 301/601 (Main Highway) adjacent to the north end of Bridge Street (Road 167) in Bamberg.
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Char-Augusta Road (Road 86) crosses U.S. 301/601 northwest from U.S. 78 at Midway to S.C. 70 at Finland.
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Crossing the South Fork of the Edisto River, U.S. 301/601 (Main Highway) north enter Orangeburg County.
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Bypassing the town of Cope, U.S. 301/601 (Bamberg Road) proceed northeast to cross a CSX Railroad line.
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Legrand Smoak Street (Road 33) head southeast from a traffic light along U.S. 301/601 to the town of Cordova and northwest to nearby S.C. 70 (Binnicker Bridge Road).
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U.S. 301/601 north converge with the east end of S.C. 70 at the succeeding intersection.
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A 29.99 mile long highway, S.C. 70 travels west to U.S. 321 at Denmark and U.S. 278 at Barnwell.
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Continuing east into Edisto, U.S. 301/601 (Bamberg Road) meets S.C. 4 (Neeses Highway). S.C. 4 leads 50.50 miles west to Neeses, Springfield and U.S. 78 at Aiken.
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An unmarked overlap with U.S. 301/601 takes S.C. 4 east 2.02 miles to Stonewall Jackson Boulevard in Orangeburg.
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U.S. 301/601 (Old Edisto Road) enter the city of Orangeburg east ahead of Cannon Bridge Road (Road 49).
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Cannon Bridge Road (Road 49) stems 9.11 miles south to Highland Park and River Drive (Road 39).
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S.C. 33 (Russell Street) commences north from U.S. 301/601 (John C. Calhoun Drive) just beyond the North Fork of the Edisto River.
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S.C. 33 parallels U.S. 301/601 northeast to Downtown Orangeburg beyond Edisto Memorial Gardens. The state highway continues to South Carolina State University and Cameron.
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Forming a 5.25 mile long loop, U.S. 601 Truck encircles Orangeburg southeast along S.C. 4 and north along U.S. 21/178 to U.S. 601 along Magnolia Street.
11/21/21

S.C. 4 east accompanies U.S. 601 Truck (Stonewall Jackson Boulevard) for 1.91 miles to U.S. 21 at U.S. 21 Business (Rowesville Road).
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U.S. 178 Business constitutes a 4.40 mile long route along Broughton Street and Charleston Highway across the city of Orangeburg.
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U.S. 178 Business (Broughton Street) intersects U.S. 301/601 three blocks south of S.C. 33 (Russell Street) and Downtown Orangeburg.
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Paralleling a Norfolk Southern Railroad line, U.S. 21 Business (Magnolia Street) heads 1.20 miles north from U.S. 178 Business (Broughton Street) to the northeast split of U.S. 301/601 (John C. Calhoun Drive).
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Despite the signed route of U.S. 601 Truck along S.C. 4 and U.S. 21, another truck route for U.S. 601 is acknowledged along the continuation of U.S. 301 (John C. Calhoun Drive) to the southeast.
11/21/21

U.S. 601 accompanies U.S. 21 Business (Magnolia Street) north for 1.16 miles to U.S. 21 (Chestnut Street) en route to St. Matthews. U.S. 301 runs east from Orangeburg to Santee.
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