In Ohio, there are a bunch of pointless multiplexes to take a number of routes into Cleveland's Public Square including US 42, US 322, US 422, SR 3, SR 43, SR 8, SR 14, and SR 87. I'd truncate back the multiplexed state routes and 3-digit US routes instead of overloading with a bunch of routes.
West Virginia now has the useless multiplex of US 48 with US 33 and then US 219 for 70 miles between Weston and Thomas so that all of Corridor H has a single number. US 48 also has useless multiplexes with WV 32, WV 93, WV 55, and VA 55 where the state routes could all be truncated back.