Exit numbers along Interstate 585 use the mileposts for U.S. 176 starting from the North Carolina state line northwest of Landrum. The expressway along U.S. 176 (N Pine Street) extends northwest from Business Loop I-85 to Fairforest Road, just shy of I-85.
Plans were made to extend the Interstate standard portion of U.S. 176 all the way to I-85 as part of a two phase project announced in 2001. Work focused on upgrading N Pine Street between I-585 and Valley Falls Road. Construction included the removal of an at-grade intersection with Tenosha Drive, access and capacity improvements to roads leading to the adjacent USC Upstate campus, conversion of the interchange with Valley Falls Road from a folded diamond to a full diamond, relocation of Hodge Road to no longer intersect U.S. 176 and the realignment of ramps with Business Loop I-85.1 The $63 million project commenced in 2003 and was completed at a ribbon cutting ceremony held on October 25, 2006.2