U.S. 301/601 South

Confirming markers posted west of U.S. 21 Business (Magnolia Street).
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U.S. 178 Business (Broughton Street) meets U.S. 301/601 (John C. Calhoun Drive) just south of Downtown Orangeburg.
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U.S. 178 Business constitutes a 4.40 mile long loop across Orangeburg.
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U.S. 601 Truck returns to U.S. 601 from Magnolia Street in north Orangeburg alongside S.C. 4 on Stonewall Jackson Street. S.C. 4 is not marked along U.S. 301/601 until it branches west along Neeses Highway at Edisto.
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U.S. 301/601 (John C. Calhoun Drive) converge with the west end of S.C. 33 (Russell Street) just after S.C. 4 and Riverside Drive.
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Although it is not acknowledged, S.C. 4 overlaps with U.S. 301/601 south for 2.02 miles.
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Cannon Bridge Road (Road 49) south connects with Cordova Road (Road 90) west to the town of Cordova.
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S.C. 4 continues 50.50 miles west to the town of Neeses, town of Springfield and the city of Aiken.
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S.C. 4 (Neeses Highway) separates from U.S. 301/601 (Old Edisto Drive) at a wye intersection.
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Curving southwest, U.S. 301/601 (Bamberg Road) advance to the east end of S.C. 70 (Binnicker Bridge Road).
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S.C. 70 branches west from U.S. 301/601 to Denmark, Hilda and Barnwell.
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S.C. 332 (Slab Landing Road) stems northwest from U.S. 601/301 into the nearby town of Cope.
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18.07 miles in length, S.C. 332 travels northwest to U.S. 321 at Norway and S.C. 4 east of Springfield.
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U.S. 301/601 span the South Fork of the Edisto River south into Bamberg County.
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U.S. 301/601 (Main Highway) meet U.S. 78 (Heritage Highway) in Downtown Bamberg.
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U.S. 78 travels northwest from Bamberg to Denmark and Aiken and southeast to Branchville and Charleston.
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