U.S. 601 South - St. Matthews to Orangeburg

Confirming marker posted south of U.S. 176 (Old State Road) on U.S. 601 (St. Mathews Road) at Wertz Crossroads.
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U.S. 601 (St. Matthews Road) crosses into Orangeburg County south of Riley.
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Advancing south from Calhoun County, U.S. 601 next reaches the rural settlement of Jamison.
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U.S. 601 shifts east away from the parallel Norfolk Southern Railroad line into a six-ramp parclo interchange (Exit 145) with Interstate 26.
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Addressing a weaving traffic pattern, loop ramps at the exchange joining I-26 with U.S. 601 were removed during construction from August 2016 to May 2017.
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Interstate 26 stays east of Orangeburg southward toward Charleston.
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Commercial frontage lines U.S. 601 (St. Matthews Road) south from Interstate 26 to Orangeburg.
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State A&M Road stems west from U.S. 601 (Magnolia Street) to Hillcrest Recreational Park.
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U.S. 601 (Magnolia Street) south meets U.S. 21/178 (Chestnut Street) at the north end of U.S. 21 Business. U.S. 21/178 encircle Orangeburg along an arterial bypass.
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The truck route for U.S. 601 accompanies U.S. 21/178 (Chestnut Street) south to Charleston Highway and along S.C. 4 (Stonewall Jackson Boulevard) northwest back to U.S. 601.
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U.S. 21 Business commences south alongside U.S. 601 (Magnolia Street) toward Downtown Orangeburg. The bannered route run 2.73 miles south to U.S. 21 at Rowesville Road.
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U.S. 178 travels northwest from Orangeburg to North and southeast to Bowman.
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U.S. 21 Business is not acknowledged on the succeeding confirming marker south on Magnolia Street.
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Continuing beyond Claflin University, U.S. 601/21 Business (Magnolia Street) meet S.C. 33 (Russell Street) east of Downtown Orangeburg.
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S.C. 33 south passes through Downtown west to U.S. 301/601 by the North Fork of the Edisto River. S.C. 33 north heads to South Carolina State University and Cameron.
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U.S. 601/21 Business advance south from S.C. 33 (Russell Street) to meet U.S. 301 (John C. Calhoun Drive), where U.S. 601 turns southwest.
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U.S. 301/601 overlap south to Bamberg. U.S. 21 Business (Magnolia Street) continues another 1.57 miles to U.S. 21 at S.C. 4/U.S. 601 Truck. U.S. 301 north connects Orangeburg with I-95 near Santee.
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