U.S. 15 North - Walternboro to Santee

U.S. 15 commences along Jefferies Boulevard north from U.S. 17 ALT (Wichman Street) and Downtown Walterboro. No confirming marker is posted ahead of S.C. 64 Business (Paul Street).
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S.C. 64 Business (Paul Street) provides a cutoff from U.S. 17 ALT south 0.28 miles to U.S. 15 north.
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Crossing Ireland Creek, S.C. 64 Business combines with U.S. 15 (Jeffries Boulevard) north 0.40 miles.
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S.C. 64 Business separates with U.S. 15 (Jeffries Boulevard) north along Bells Highway.
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S.C. 64 Business branches northwest 0.76 miles to S.C. 64 (Robertson Boulevard). The town of Ehrhardt is 26 miles away along S.C. 64 at U.S. 601.
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S.C. 64 is unmarked along U.S. 15 (Jefferies Boulevard) north at Robertson Boulevard. Heading west to I-95 and east to Lowcountry Regional Airport (RBW) and U.S. 17 ALT, S.C. 64 bypasses Downtown Walterboro to the north.
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Tuskegee Airmen Drive (Road 754) runs 1.77 miles east from U.S. 15 at Academy Road (Road 130) to Thunderbolt Drive (Road 461).
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McLeod Road (Road 127 / Road 15) stems 2.53 miles west from U.S. 15 to Interstate 95 at Exit 62.
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The first confirming marker for U.S. 15 north does not appear until beyond Pleasant Grove Road (Road 15).
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Canadys is an unincorporated community centered at the crossroads of U.S. 15 (Jefferies Highway) and S.C. 61 (Augusta Highway).
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Spanning the Edisto River across the Grady C. Murray Bridge, U.S. 15 north enters Dorchester County.
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U.S. 15 north at the settlement of Grover.
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St. George is the seat of Dorcester County. U.S. 15 follows Parler Avenue through the town limits.
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Parler Avenue north at George Street in the St. George business district.
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Signs for U.S. 15 and U.S. 78 along Parler Avenue in Downtown St. George were not reinstalled after street lights and the traffic signals at Memorial Boulevard were replaced by 2015.
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Crossing Indian Field Swamp
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Paralleling I-26 to the south between Bowman and Harleyville, U.S. 178 meets U.S. 15 at Rosinville.
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No shields are posted for U.S. 176 in either direction of U.S. 15.
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A rural cloverleaf interchange joins U.S. 15 with Interstate 26 at Exit 172.
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Turning east, U.S. 15 northbound traverses Four Hole Swamp into Orangeburg County.
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S.C. 314 (Bunch Ford Road) branches 2.16 miles east from U.S. 15 (Bass Drive) to U.S. 176 (Old State Road) near Holly Hill. Signs acknowledging S.C. 314 at the rural wye intersection have been missing since 2018.
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U.S. 176 (Old State Road), S.C. 45 (Branchdale Highway) west and U.S. 15 (Bass Drive) converge at a five point intersection in Wells.
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U.S. 176 travels northwest from Holly Hill across U.S. 15 to I-95 at Exit 90 en route to Cameron and Columbia.
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S.C. 45 (Branchdale Highway) runs 8.00 miles east to S.C 453 (Eutaw Road) at Eutawville.
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U.S. 15 continues north from Wells to a diamond interchange (Exit 93) with Interstate 95.
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S.C. 210 (Vance Road) crosses paths with U.S. 15 west from S.C. 6 in Vance and northeast from U.S. 176 at Providence.
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S.C. 267 (Tee Vee Road) constitutes a 5.48 mile long highway providing a cutoff from U.S. 15 north to S.C. 6 west for Elloree.
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Turning northeast toward Santee, U.S. 15 (Bass Drive) meets U.S. 301 (Five Chop Road).
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U.S. 15 combines with U.S. 301 (Five Chop Road) east 1.33 miles to Interstate 95 north across Lake Marion. The overlap is not acknowledged however, while Bass Drive continues north as unsigned U.S. 15 Connector.
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Bass Drive (U.S. 15 CON) enters the town of Santee just north of U.S. 15/301 (Five Chop Road).
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U.S. 15 Connector runs 2.14 miles north to S.C. 6 (Old Number Six Highway) in Santee.
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S.C. 6 parallels the Santee River along Lake Marion northwest to Elloree and St. Matthews and southeast from Santee to Vance and Eutawville.
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U.S. 15/301 formerly combined with S.C. 6 (Old Number Six Highway) east from Bass Drive 0.43 miles to the northbound entrance ramp for Interstate 95 at Exit 98.
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