U.S. 301 South - Florence to Turbeville

U.S. 301 parts ways with U.S. 76 (E Palmetto Street) at S.C. 327. U.S. 301 follows Freedom Boulevard, an arterial bypass of Florence completed by 2007.
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U.S. 301 (Freedom Boulevard) curves southwest beyond Canal Branch.
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Wallace Road (Road 681) runs 0.66 miles south to Old Wallace Gregg Road (Road 918) at Kenwood Acres and north 1.10 miles to U.S. 76 (Palmetto Street).
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National Cemetery Road (Road 13) crosses U.S. 301 (Freedom Boulevard) west from Price Crossroads to Florence.
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U.S. 301 converges with S.C. 51 (Pamplico Highway) between Florence Medical Center and Independence Center retail plaza.
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Joining Florence with Georgetown, S.C. 51 travels southeast to Pamplico and U.S. 378 at Salem.
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U.S. 301 (Freedom Boulevard) and the truck route for U.S. 52 span a CSX Railroad line south of Church Street (Road 12).
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Curving west toward Third Loop Road (Road 588), U.S. 301 next meets U.S. 52 (Irby Street).
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Third Loop Road extends northwest from U.S. 52 and U.S. 301 (Freedom Boulevard) across residential areas of southwest Florence.
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U.S. 301 turns south alongside U.S. 52 (Irby Street) for 5.85 miles to Pine Grove, Danwood and Effingham.
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U.S. 52 (Irby Street) heads 3.64 miles north to U.S. 76 (Palmetto Street) at Downtown Florence.
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U.S. 52/301 (Irby Street) combine south ahead of Middle Swamp.
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Alligator Road (Road 107) east and E Howe Springs Road (Road 57) come together at U.S. 52/301 in Pine Grove.
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U.S. 301 separates from U.S. 52 (S Irby Street) at the south end of S.C. 327 (Effingham Highway).
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S.C. 327 comprises a 22.62 mile long loop to the east of Florence between Effingham and Interstate 95 at Exit 170.
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U.S. 52 continues south from Effingham to Coward. U.S. 378 at Lake City and Kingstree en route to Charleston.
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U.S. 301 advances west along Olanta Highway from U.S. 52 to Elim.
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Reassurance marker posted south of Stagecoach Road (Road 136) at Elim.
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S Hill Road (Road 38) is part of a route with Center Road (Road 83) and Honda Way north 11.79 miles to U.S. 76 (E Smith Street) in the town of Timmonsville.
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S.C. 403 (N Bethel Road) south toward Lake City crosses U.S. 301 (N Jones Road) at Kelley Crossroads.
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U.S. 301 (N Jones Road) at Main Street (Road 73) in the town of Olanta.
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Entering Clarendon County, U.S. 301 south is again named Olanta Highway.
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U.S. 301 (Olanta Highway) enters the town of Turbeville just ahead of U.S. 378 (Turbeville Highway).
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U.S. 378 enters Turbeville west from Lake City.
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U.S. 301 joins U.S. 378 west onto Main Street 0.72 miles through Turbeville.
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S.C. 58 stems northwest from U.S. 301/378 (Main Street) along Gamble Street in Turbeville.
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U.S. 378 separates from U.S. 301 south just beyond S.C. 58 (Gamble Street). S.C. 58 runs 10.47 miles north to S.C. 341 outside Lynchburg.
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U.S. 378 (Clarence Coker Highway) branches west from U.S. 301 to the city of Sumter. U.S. 301 remins southwest to the Clarendon County seat of Manning.
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U.S. 378 connects with Interstate 95 at Exit 135, 4.3 miles to the west.
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Calvert Street south and Park Street north from Turbeville Town Hall tie into a five point intersection where U.S. 301 and U.S. 378 split.
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