I-16 through I-29 and Signed Branch Routes

Interstate South/West End North/East End
16 Macon, GA Savannah, GA
516 GA Savannah Garden City
17 Phoenix, AZ Flagstaff, AZ
19 Nogales, AZ Tucson, AZ
20 near Kent, TX Florence, SC
220 LA Shreveport Bossier City
220 MS Jackson Ridgeland
520 GA/SC Augusta, GA North Augusta, SC
820 TX Benbrook Kennedale
22 Byhalia, MS Birmingham, AL
24 Pulleys Mill, IL Chattanooga, TN
25 Las Cruces, NM Buffalo, WY
225 CO Denver Aurora
26 Kingsport, TN Charleston, SC
126 SC St. Andrews Columbia
526 SC Charleston Mt. Pleasant
27 Lubbock, TX Amarillo, TX
29 Kansas City, MO Canadian Border – Pembina, ND
129 IA/NE South Sioux City, NE Sioux City, IA
229 MO St. Joseph Amazonia
229 SD Sioux Falls Sioux Falls
I-25 north at Wardwell Rd - Casper, WY
Interstate 25 closed sign posted along northbound on the outskirts of Casper, Wyoming. Flashing lights illuminate during periods of closure. 08/06/13

Inclement weather, traffic alerts and other advisories may result in a closure of Interstate highways in the high plains. During these periods, traffic is directed to turn around or wait until the freeway reopens.

I-26 east at Holston River S Fork - Kingsport, TNfk-holston-river
Interstate 26 eastbound on the viaduct spanning the Holston River South Fork in Kingsport, Tennessee. 06/25/12

The stretch of Interstate 26 south of Johnson City, Tennessee angles in such a way that eastbound flows westbound and vice versa. I-25 east of Santa Fe, New Mexico and I-64 in Hampton Roads, Virginia are other examples where the cardinal direction of an Interstate does this.