State Road 21 North - Melrose to Middleburg

North

The city of Keystone Heights is seven miles north of SR 26 and Melrose along SR 21.
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North from Melrose, SR 21 enters the southwestern corner of Clay County for 0.83 miles.
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Running just east of Lake Santa Fe and the Alachua County line, SR 21 proceeds north into the southeastern wedge of Bradford County.
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The western leg of County Road 214 encircles Lake Geneva east between SR 21 and SR 100 along a 4.64 mile long course.
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CR 214 connects with SR 100 south of the unincorporated community of Lake Geneva in Clay County.
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A sparsely signed route, County Road 21B follows a convoluted loop west from SR 21 to Little Santa Fe Lake and north to SR 100 beyond Silver Lake.
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Confirming marker posted along SR 21 north of SR 100 (Walker Drive) and Downtown Keystone Heights.
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Middleburg is 28 miles to the north of Keystone Heights. Jacksonville is 48 miles away via SR 21, U.S. 17 and the old alignment of U.S. 17 through Riverside and Brooklyn in The River City.
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SR 21 spans the waterway connecting Lake Brooklyn and Brooklyn Bay just north of the Keystone Heights city line.
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Continuing northeast past Loch Lommond, SR 21 meets CR 352 east near Spring Lake.
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Encircling Spring Lake, White Sands Lake and Gator Bone Lake, CR 352 spurs 4.80 miles east to Christian Camp Road and the south entrance into Gold Head Branch State Park.
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SR 21 remains northeast between Camp Blanding State Wildlife Management Area and Gold Head Branch State Park.
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The north entrance of Gold Head Branch State Park ties into SR 21 near Sheeler Lake.
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Clay County Road 315C extends 7.87 miles north from Putnam County Road 315 to SR 21 across from Camp Blanding Joint Training Center.
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South from CR 315C, CR 315 travels to SR 100 at Grandin, SR 20 at Interlachen and SR 40 near Silver Springs.
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Curving north around the periphery of Camp Blanding, SR 21 meets CR 315 (Sharron Road) east at an unmarked intersection. The northern leg of CR 315 heads 14.43 miles northeast to the Ates Creek Tract of Belmore State Forest and SR 16 near Green Cove Springs.
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SR 16 connects the Bradford County seat of Starke with Penney Farms and the Clay County seat of Green Cove Springs.
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There are no shields posted for SR 16 along either direction of SR 21. The lone reference of the state road are the street signs at the span wire traffic signal array.
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SR 21 bee lines north from SR 16 along the Satsuma Tract of Belmore State Forest.
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Entering the unincorporated community of Middleburg, SR 21 converges with CR 215 north beyond Bull Creek.
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A 6.13 mile long highway, CR 215 provides a cut off from SR 16 east at Camp Blanding to SR 21 north through Middleburg.
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Measuring 20.39 miles in length, County Road 218 crosses Middleburg northwest from SR 16 at Penney Farms en route to U.S. 301 near Maxville.
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The Ravines is a development north off CR 218, 0.9 miles east of SR 21 (Blanding Boulevard).
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Construction underway from February 2020 to late 2022 expanded SR 21 (Blanding Boulevard) north from four to six lanes and improved the intersection with CR 218.¹
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References:

1. State Road 21 from CR-218 to Black Creek Improvements. Florida Department of Transportation (FDOT), project web page. https://nflroads.com/ProjectDetails.aspx?p=5118

Connect with:

State Road 16

State Road 26

State Road 100

Clay County Road 215

Clay County Road 218

County Road 315

Page Updated Wednesday August 13, 2025.