U.S. 21 South - Orangeburg to Yemassee

U.S. 21 is unmarked along Rowesville Road leading south from U.S. 21 Business, U.S. 601 Truck and S.C. 4 (Stonewall Jackson Boulevard).
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U.S. 21 expands into a divided highway south ahead of Gulbrandsen Road (Road 1449).
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The four lane section of U.S. 21 (Rowesville Road) concludes south of Southern Patio Parkway.
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U.S. 21 runs through the east side of the town of Rowesville.
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Entering the town of Branchville along U.S. 21 (Freedom Road) south.
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The west end of S.C. 210 (Bowman Branch Highway) ties into U.S. 21 just beyond North Street in Branchville.
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U.S. 21 (Freedom Road) expands to a four lane boulevard leading south to U.S. 78 (Dorange Road) east.
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U.S. 78 west joins U.S. 21 (Freedom Road) south 0.20 miles to Edward Street in the Branchville business district. U.S. 78 east leads to St. George, Summerville and Charleston.
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U.S. 78 continues west from Branchville to Bamberg, Aiken and North Augusta.
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Spanning the Edisto River, U.S. 21 (Freedom Road) enters the eastern tip of Bamberg County.
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U.S. 21 south next meets S.C. 61 (Edisto River Road) at Whetsone Crossroads.
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S.C. 61 travels southeast to Walterboro and Charleston and northwest to U.S. 78.
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Ruffin Road (Road 15) stems southeast from U.S. 21 (LowCountry Highway) at Ruffin to Stokes and Rhodes Crossroads.
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U.S. 21 (LowCountry Highway) converges with U.S. 17 ALT (Hendersonville Highway) at a rural wye intersection south of Jonesville.
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U.S. 21/17 ALT (Hendersonville Highway) bee line four miles southwest to the town of Yemassee.
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U.S. 21/17 ALT pass through the easternmost section of Hampton County for 3.22 miles.
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Salkahatchie Road (Road 13) angles across U.S. 21/17 ALT at a flasher.
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