U.S. 50 shares substantial portions of its alignment across the Beehive State with other numbered highways. This includes an 89.40 mile overlap with U.S. 6 from the Ferguson Desert and Nevada state line to Sevier Valley and the city of Delta, a 10.09 mile concurrency with Interstate 15 from Holden to Scipio, a 1.765 mile overlap with U.S. 89 through Salina, and 174.94 miles with I-70 to the Colorado state line.
The first independent section of U.S. 50 angle southeast across the Pahvant Valley between Delta and Holden. Branching south from I-15, the second portion runs between the Pahvant Range and Valley Mountains to Scipio Lake and the Sevier County line. Turning east across the Valley Mountains, U.S. 50 reaches Salina where it combine with U.S. 89 south to Interstate 70.
Prior to the completion of Interstate 70 through the San Rafael Reef, the segment of U.S. 6 through Delta, Santaquin, Spanish Fork and Price was also designated as U.S. 50. Also at that time, U.S. 89-91 north to Salt Lake City was cosigned as U.S. 50 Alternate. When the initial two lane segment of Interstate 70 opened between Salina and Green River in 1976, U.S. 50 was moved from its concurrency with U.S. 6 onto I-70, along with taking over former SR 26 between Delta and Scipio and former SR 63 between Scipio and Salina.