Within the Palmetto State, U.S. 321 branches north from U.S. 17 at Hardeville in the LowCountry. U.S. 321 vacates South Carolina north of Clover to Gastonia, North Carolina.
U.S. 321 South Carolina Guides
U.S. 321 runs alongside a CSX Railroad corridor north from S.C. 119 near Scotia to Estill, Luray and Fairfax. The two continue northward to Sycamore and Ulmer, where U.S. 301 ties in from Allendale to the southwest. U.S. 301/321 separate just into Bamburg County, with U.S. 301 shifting eastward to Bamberg and U.S. 321 again traveling alongside the CSX Railroad to Olar, Denmark and Norway.
Continuing into Lexington County, U.S. 321 travels through Swansea and Gaston. U.S. 21/176 combine with U.S. 321 along Charleston Highway north from near Dixiana into the city of Cayce. The three routes line Knox Abott Drive east to Blossom Street across the Congaree River into Columbia.
U.S. 21/176/321 circumvent Downtown Columbia north along Huger Street to I-126/U.S. 76 and east on Elmwood Avenue to Main Street. U.S. 176 eventually branches northwest to St. Andrews, followed by U.S. 21 northeast to Blythewood. U.S. 321 continues northward to Winnsboro in Fairfield County, where the first of three business routes is designated.
U.S. 321 Business loops 4.35 miles east from U.S. 321 into Winnsboro. U.S. 321 Business in Chester follows Columbia Street and Center Street/Road along a 3.67 mile route through Downtown. North into York County, U.S. 321 passes through McConnells to the city of York, where a 2.50 mile long business route loops to the east.
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| S.C. 70 overlaps with U.S. 321 (Carolina Highway) south for 0.68 miles through the city of Denmark in Bamberg County. 04/10/16 |
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| S.C. 70 continues 14.54 miles west from U.S. 321 (Carolina Highway) at Hagood Avenue in Denmark to U.S. 278 (Jackson Street) in Barnwell. 04/10/16 |
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| S.C. 64 (LowCountry Highway) intersects U.S. 321 (Carolina Highway) in the town of Olar. S.C. 64 leads west to U.S. 278 in Barnwell and east to U.S. 601 at Ehrhardt, S.C. 217 at Lodge and I-95 at Walterboro. 04/10/16 |
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| U.S. 321 (Cotton Hill Road) converges with the south end of U.S. 601 (Cypress Branch Road) midway between Robertville and Tarboro. 09/16/21 |
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| U.S. 601 leads back north to Hampton and Orangeburg. 09/16/21 |
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| U.S. 601 travels 316 miles overall from Mount Airy, North Carolina to U.S. 321 in Jasper County. Prior to 1975, U.S. 601 overlapped with U.S. 321 south to U.S. 17 in Hardeeville. 09/16/21 |
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| U.S. 321 (Deerfield Road) heads south into the city of Hardeeville ahead of S.C. 46 (Church Road). 03/15/10 |
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| S.C. 46 travels 17.33 miles east from U.S. 321 to Pritchardville and U.S. 278 at Bluffton. 03/15/10 |
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| S.C. 46 formerly split with U.S. 321 (Deerfield Road) south at a wye intersection. 03/15/10 |
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| U.S. 321 (Deerfield Road) spans a CSX Railroad line just ahead of the wye intersection with U.S. 17 (Whyte Hardee Boulevard). 11/13/06 |
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| U.S. 321 ends at U.S. 17 (Whyte Hardee Boulevard) with no signage. The distance sign for Savannah pictured here was removed. 11/13/06 |
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| Alexander Road (Road 56) south at U.S. 21/176/321 (Knox Abbott Drive) and Axtel Drive in Cayce. 04/15/12 |
Photo Credits:- 11/13/06 by AARoads.
- 03/15/10 by AARoads.
- 04/15/12 by AARoads.
- 04/10/16 by Carter Buchanan.
- 09/16/21 by AARoads.
Connect with:
Interstate 20
Interstate 26
Interstate 126
U.S. 1
U.S. 17
U.S. 21
U.S. 76
U.S. 78
U.S. 176
U.S. 178
U.S. 278
U.S. 378
U.S. 601
Highway 46
Highway 64
Page Updated 12-07-2022.
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