Interstate 10 spans the width of Louisiana from Orange, Texas east to Lake Charles, Lafayette, Baton Rouge, New Orleans and Slidell. With a limited number of services, the freeway travels along a series of viaducts over the Atchafalaya Basin between Henderson and Ramah. An 11.2 mile long exit less stretch ensues from there east to western reaches of the Baton Rouge area at Port Allen. The Horace Wilkinson Bridge, a high rise cantilever span, takes I-10 across the Mississippi to the southwest of Downtown Baton Rouge.
The six-lane span transitions I-10 onto a viaduct above the Baton Rouge street grid and through to the directional T interchange with Interstate 110 north. Interstate 10 reduces to two through lanes in both directions through the substandard exchange with I-110 north to Downtown and Metro Airport. Turning southeast from the bottleneck, the freeway expands again to six lanes and lowers to grade level beyond Washington Street.
I-10 crosses City Park Lake to the northeast of Louisiana State University (LSU) and ahead of a commercialized corridor at Exits 157A, 157B and 158. East from College Drive, the freeway expands to eight overall lanes leading to the split with Interstate 12 east. I-12 takes the bulk of through traffic east to Hammond and Slidell, while I-10 continues on a southeasterly heading toward Gonzales, Laplace and New Orleans.
Advancing southeast through the southeastern suburbs of Baton Rouge, I-10 retains six overall lanes with auxiliary lanes added between ramps. The freeway passes by the Mall of Louisiana at Bluebonnet Boulevard, and across a commercial strip anchored by big box retail at Louisiana 3246 (Siegan Lane). The six-lane section concludes at Louisiana 42 (Exit 166). I-10 continues south by a number of subdivisions as it arcs by the city of Gonzalez. Once past the town of Sorrento, Interstate 10 traverses wetland areas for a 38-mile span to Kenner.