Existing in three segments between the Gulf Coast and the northern tip of Lake Okeechobee, Florida 78 travels just over 72 miles through Lee, Glades and Okeechobee counties. Its westernmost segment stretches 18.9 miles from Lee County 765 (Burnt Store Road) and Lee County 884 (Veterans Parkway) in western Cape Coral to North Fort Myers and Florida 31 just north of the Caloosahatchee River. A second Florida 78 picks back up in Glades County at an intersection with Florida 29 north of La Belle and shoots east 14.8 miles to Ortona and U.S. 27. The final segment of SR 78 stems north from U.S. 27 immediately west of Moore Haven and follows the western shores of the Herbert Hoover Dike and Lake Okeechobee 34.2 miles to its terminus with U.S. 98 & 441 just south of the town of Okeechobee.
Two former segments of Florida 78 now exist as county-maintained routes within Lee and Hendry counties. One segment of Lee County 78 continues from the western terminus of Florida 78 in Cape Coral 5.5 miles to Matlacha and Pine Island while another Lee County 78 extends east from Florida 31 toward Alva and into Hendry County. Paralleling the Caloosahatchee River, Hendry County 78 continues eastward toward La Belle and its end at Florida 29.
Page Updated 08-03-2014.