The primary freeway route through Reno-Sparks is Interstate 580 and U.S. 395, which bypasses old U.S. 395 along Virginia Street and stays to the east of Downtown Reno. The Interstate 580 Freeway Extension Project, which connected disparate segments of U.S. 395 freeway near Washoe Lake and Mt. Rose Junction (bypassing Pleasant Valley), was completed in August 2012. As of August 2, 2017, Interstate 580 was fully opened from Interstate 80 at Reno southward to the separation of U.S. 50 west and 395 south in Carson City. The section of Interstate 580 and U.S. 395 through the city of Reno is named the Martin Luther King, Jr. Memorial Highway, with the older portions originally called the North-South Freeway.
South from Carson City through Minden, U.S. 395 is the primary route through the Eastern Sierra. Part of a 1,305 mile long route that spans four states, U.S. 395 is the Three Flags Highway. Entering Nevada at Topaz Lake, U.S. 395 turns northwest by the Pine Nut Mountains to enter Carson Valley ahead of Gardnerville. Overtaking MSR 88 north from Alpine County, California, U.S. 395 proceeds due north to cross the Carson River ahead of Eagle Valley and the state capital of Carson City. U.S. 395 accompanies U.S. 50 along the Carson City Freeway (I-580) to bypass Downtown, with U.S. 395 Business following the former route along Carson Street.
U.S. 50 splits with I-580 & U.S. 395 at William Street to the continuation east to Fallon. North from there, the freeway proceeds past Washoe Lake and Mt. Rose Junction before entering Truckee Meadows and the Reno-Sparks metropolitan area. Traveling north into Reno, Interstate 580 and U.S. 395 have direct connections with Reno-Tahoe International Airport (RNO).
I-580 ends at Interstate 80 (Exit 68). U.S. 395 continues northwest, aiming back into California at Bordertown as a full freeway. U.S. 395 will travel as a freeway or expressway northward to Susanville.